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1.
arxiv; 2021.
Preprint in English | PREPRINT-ARXIV | ID: ppzbmed-2105.01142v2

ABSTRACT

State governments in the U.S. have been facing difficult decisions involving tradeoffs between economic and health-related outcomes during the COVID-19 pandemic. Despite evidence of the effectiveness of government-mandated restrictions mitigating the spread of contagion, these orders are stigmatized due to undesirable economic consequences. This tradeoff resulted in state governments employing mandates in widely different ways. We compare the different policies states implemented during periods of restriction (lockdown) and reopening with indicators of COVID-19 spread and consumer card spending at each state during the first wave of the pandemic in the U.S. between March and August 2020. We find that while some states enacted reopening decisions when the incidence rate of COVID-19 was minimal or sustained in its relative decline, other states relaxed socioeconomic restrictions near their highest incidence and prevalence rates experienced so far. Nevertheless, all states experienced similar trends in consumer card spending recovery, which was strongly correlated with reopening policies following the lockdowns and relatively independent from COVID-19 incidence rates at the time. Our findings suggest that consumer card spending patterns can be attributed to government mandates rather than COVID-19 incidence in the states. We estimate the recovery in states that reopened in late April was more than the recovery in states that did not reopen in the same period - 15% for consumer card spending and 18% for spending by high income households. This result highlights the important role of state policies in minimizing health impacts while promoting economic recovery and helps planning effective interventions in subsequent waves and immunization efforts.


Subject(s)
COVID-19
2.
Estee Y Cramer; Evan L Ray; Velma K Lopez; Johannes Bracher; Andrea Brennen; Alvaro J Castro Rivadeneira; Aaron Gerding; Tilmann Gneiting; Katie H House; Yuxin Huang; Dasuni Jayawardena; Abdul H Kanji; Ayush Khandelwal; Khoa Le; Anja Muhlemann; Jarad Niemi; Apurv Shah; Ariane Stark; Yijin Wang; Nutcha Wattanachit; Martha W Zorn; Youyang Gu; Sansiddh Jain; Nayana Bannur; Ayush Deva; Mihir Kulkarni; Srujana Merugu; Alpan Raval; Siddhant Shingi; Avtansh Tiwari; Jerome White; Spencer Woody; Maytal Dahan; Spencer Fox; Kelly Gaither; Michael Lachmann; Lauren Ancel Meyers; James G Scott; Mauricio Tec; Ajitesh Srivastava; Glover E George; Jeffrey C Cegan; Ian D Dettwiller; William P England; Matthew W Farthing; Robert H Hunter; Brandon Lafferty; Igor Linkov; Michael L Mayo; Matthew D Parno; Michael A Rowland; Benjamin D Trump; Sabrina M Corsetti; Thomas M Baer; Marisa C Eisenberg; Karl Falb; Yitao Huang; Emily T Martin; Ella McCauley; Robert L Myers; Tom Schwarz; Daniel Sheldon; Graham Casey Gibson; Rose Yu; Liyao Gao; Yian Ma; Dongxia Wu; Xifeng Yan; Xiaoyong Jin; Yu-Xiang Wang; YangQuan Chen; Lihong Guo; Yanting Zhao; Quanquan Gu; Jinghui Chen; Lingxiao Wang; Pan Xu; Weitong Zhang; Difan Zou; Hannah Biegel; Joceline Lega; Timothy L Snyder; Davison D Wilson; Steve McConnell; Yunfeng Shi; Xuegang Ban; Robert Walraven; Qi-Jun Hong; Stanley Kong; James A Turtle; Michal Ben-Nun; Pete Riley; Steven Riley; Ugur Koyluoglu; David DesRoches; Bruce Hamory; Christina Kyriakides; Helen Leis; John Milliken; Michael Moloney; James Morgan; Gokce Ozcan; Chris Schrader; Elizabeth Shakhnovich; Daniel Siegel; Ryan Spatz; Chris Stiefeling; Barrie Wilkinson; Alexander Wong; Sean Cavany; Guido Espana; Sean Moore; Rachel Oidtman; Alex Perkins; Zhifeng Gao; Jiang Bian; Wei Cao; Juan Lavista Ferres; Chaozhuo Li; Tie-Yan Liu; Xing Xie; Shun Zhang; Shun Zheng; Alessandro Vespignani; Matteo Chinazzi; Jessica T Davis; Kunpeng Mu; Ana Pastore y Piontti; Xinyue Xiong; Andrew Zheng; Jackie Baek; Vivek Farias; Andreea Georgescu; Retsef Levi; Deeksha Sinha; Joshua Wilde; Nicolas D Penna; Leo A Celi; Saketh Sundar; Dave Osthus; Lauren Castro; Geoffrey Fairchild; Isaac Michaud; Dean Karlen; Elizabeth C Lee; Juan Dent; Kyra H Grantz; Joshua Kaminsky; Kathryn Kaminsky; Lindsay T Keegan; Stephen A Lauer; Joseph C Lemaitre; Justin Lessler; Hannah R Meredith; Javier Perez-Saez; Sam Shah; Claire P Smith; Shaun A Truelove; Josh Wills; Matt Kinsey; RF Obrecht; Katharine Tallaksen; John C. Burant; Lily Wang; Lei Gao; Zhiling Gu; Myungjin Kim; Xinyi Li; Guannan Wang; Yueying Wang; Shan Yu; Robert C Reiner; Ryan Barber; Emmanuela Gaikedu; Simon Hay; Steve Lim; Chris Murray; David Pigott; B. Aditya Prakash; Bijaya Adhikari; Jiaming Cui; Alexander Rodriguez; Anika Tabassum; Jiajia Xie; Pinar Keskinocak; John Asplund; Arden Baxter; Buse Eylul Oruc; Nicoleta Serban; Sercan O Arik; Mike Dusenberry; Arkady Epshteyn; Elli Kanal; Long T Le; Chun-Liang Li; Tomas Pfister; Dario Sava; Rajarishi Sinha; Thomas Tsai; Nate Yoder; Jinsung Yoon; Leyou Zhang; Sam Abbott; Nikos I I Bosse; Sebastian Funk; Joel Hellewell; Sophie R Meakin; James D Munday; Katharine Sherratt; Mingyuan Zhou; Rahi Kalantari; Teresa K Yamana; Sen Pei; Jeffrey Shaman; Turgay Ayer; Madeline Adee; Jagpreet Chhatwal; Ozden O Dalgic; Mary A Ladd; Benjamin P Linas; Peter Mueller; Jade Xiao; Michael L Li; Dimitris Bertsimas; Omar Skali Lami; Saksham Soni; Hamza Tazi Bouardi; Yuanjia Wang; Qinxia Wang; Shanghong Xie; Donglin Zeng; Alden Green; Jacob Bien; Addison J Hu; Maria Jahja; Balasubramanian Narasimhan; Samyak Rajanala; Aaron Rumack; Noah Simon; Ryan Tibshirani; Rob Tibshirani; Valerie Ventura; Larry Wasserman; Eamon B O'Dea; John M Drake; Robert Pagano; Jo W Walker; Rachel B Slayton; Michael Johansson; Matthew Biggerstaff; Nicholas G Reich.
medrxiv; 2021.
Preprint in English | medRxiv | ID: ppzbmed-10.1101.2021.02.03.21250974

ABSTRACT

Short-term probabilistic forecasts of the trajectory of the COVID-19 pandemic in the United States have served as a visible and important communication channel between the scientific modeling community and both the general public and decision-makers. Forecasting models provide specific, quantitative, and evaluable predictions that inform short-term decisions such as healthcare staffing needs, school closures, and allocation of medical supplies. In 2020, the COVID-19 Forecast Hub (https://covid19forecasthub.org/) collected, disseminated, and synthesized hundreds of thousands of specific predictions from more than 50 different academic, industry, and independent research groups. This manuscript systematically evaluates 23 models that regularly submitted forecasts of reported weekly incident COVID-19 mortality counts in the US at the state and national level. One of these models was a multi-model ensemble that combined all available forecasts each week. The performance of individual models showed high variability across time, geospatial units, and forecast horizons. Half of the models evaluated showed better accuracy than a naive baseline model. In combining the forecasts from all teams, the ensemble showed the best overall probabilistic accuracy of any model. Forecast accuracy degraded as models made predictions farther into the future, with probabilistic accuracy at a 20-week horizon more than 5 times worse than when predicting at a 1-week horizon. This project underscores the role that collaboration and active coordination between governmental public health agencies, academic modeling teams, and industry partners can play in developing modern modeling capabilities to support local, state, and federal response to outbreaks. f


Subject(s)
COVID-19
3.
arxiv; 2020.
Preprint in English | PREPRINT-ARXIV | ID: ppzbmed-2011.14233v1

ABSTRACT

With the emerging COVID-19 crisis, a critical task for public health officials and policy makers is to decide how to prioritize, locate, and allocate scarce resources. To answer these questions, decision makers need to be able to determine the location of the required resources over time based on emerging hot spot locations. Hot spots are defined as concentrated areas with sharp increases in COVID19 cases. Hot spots place stress on existing healthcare resources, resulting in demand for resources potentially exceeding current capacity. This research will describe a value based resource allocation approach that seeks to coordinate demand, as defined by uncertain epidemiological forecasts, with the value of adding additional resources such as hospital beds. Value is framed as a function of the expected usage of a marginal resource (bed, ventilator, etc). Subject to certain constraints, allocation decisions are operationalized using a nonlinear programming model, allocating new hospital beds over time and across a number of geographical locations. The results of the research show a need for a value based approach to assist decision makers at all levels in making the best possible decisions in the current highly uncertain and dynamic COVID environment.


Subject(s)
COVID-19
4.
arxiv; 2020.
Preprint in English | PREPRINT-ARXIV | ID: ppzbmed-2011.14231v1

ABSTRACT

The COVID19 pandemic has highlighted the lack of resilience in supply chains, as global networks fail from disruptions at single nodes and connections. Through an overview of the existing vaccine and pharmaceutical supply chain publications focusing on resilience, as well as recent papers reporting modeling of resilience in supply chains across multiple fields, we find that models for supply chain resilience are few and most of them are focused on individual dimensions of resilience rather than on comprehensive strategy necessary for scaling up vaccine production and distribution in emergency settings. We find that COVID19 resulted in a wave of interest to supply chain resilience, but publications from 2020 are narrow in focus and largely qualitative in nature; evidence-based models and measures are rare. Further, publications often focus exclusively on specific portions of the specific supply chain of interest, excluding associated supporting networks, such as transportation, social and command and control (C2) necessary for vaccine production and equitable distribution. This lack of network analysis is a major gap in the literature that needs to be bridged in order to create methods of real-time analysis and decision tools for the COVID19 vaccine supply chain. We conclude that a comprehensive, quantitative approach to network resilience that encompasses the supply chain in the context of other social and physical networks is needed in order to address the emerging challenges of a large-scale COVID-19 vaccination program. We further find that the COVID-19 pandemic underscores the necessity of positioning supply chain resilience within a multi-network context and formally incorporating temporal dimensions into analysis through the NAS definition of resilience, plan, absorb, recover, adapt, to ensure essential needs are met across all dimensions of society.


Subject(s)
COVID-19
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